The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation
- Wiseman, Helen
- Laughton, Miranda J.
- Arnstein, Henry R.V.
- Cannon, Michael
- Halliwell, Barry
Publication date
April 1990
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793Abstract
AbstractThe anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions
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