Forskolin stimulates porcine sperm capacitation by increasing calcium uptake
- Okamura, Naomichi
- Tanba, Michiko
- Fukuda, Atsunori
- Sugita, Yoshiki
- Nagai, Taku
Publication date
February 1993
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793Abstract
AbstractUsing the fluorescent calcium indicator fura-2, forskolin was found to dose-dependently cause an immediate increase in the concentration of intracellular free calcium of porcine cauda epididymal sperm. This stimulatory effect of forskolin is due to the enhancement of Ca2+ uptake by the verapamil-sensitive transporter on the sperm plasma membrane and results in the promotion of the sperm capacitation and subsequent acrosome reaction
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