AbstractWe verified the hypothesis that changes in the endogenous GM1 ganglioside density in the environment of TrkB, receptor of brain-derived neurotrophic factor, can affect receptor activity, and focused on rat cerebellar granule cells expressing both GM1 and TrkB. Changes of the amount of GM1 associated to immunoprecipitated TrkB and of receptor tyrosine phosphorylation were evaluated after treatment with phorbol-12-myristate-13-acetate (1 μM, 7 min), reported to affect the plasma membrane distribution of endogenous gangliosides in the same cells. After treatment, the amount of GM1 associated to receptor and TrkB phosphorylation decreased by about 40%. The amount of associated GM1 decreased by about 33% also after concomitant treatment ...
AbstractNeurotrophins influence growth and survival of specific populations of neurons through activ...
It has been already demonstrated that the oligosaccharide chain (OligoGM1) of the ganglioside GM1, \...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...
AbstractWe verified the hypothesis that changes in the endogenous GM1 ganglioside density in the env...
We verified the hypothesis that changes in the endogenous GM1 ganglioside density in the environment...
Experimental evidence, both in vitro and in vivo, highlight the neurotrophic and neurodifferentiativ...
Several data suggest a speci\ufb01c role of ganglioside GM1 in neuronal differentiation and developm...
The present study proposes a clarification on the molecular mechanism by which ganglioside GM1 promo...
AbstractThe expression of GABAA receptors in rat cerebellar granules in culture has been studied by ...
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by ac...
The Trk family of protein tyrosine kinases (TrkA/B/C) are receptors for neurotrophins, a family of c...
While Trk receptors can be activated in a neurotrophin-independent manner through “transactivation” ...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...
AbstractNeurotrophins are a group of secreted polypeptides, which comprises Nerve Growth Factor (NGF...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...
AbstractNeurotrophins influence growth and survival of specific populations of neurons through activ...
It has been already demonstrated that the oligosaccharide chain (OligoGM1) of the ganglioside GM1, \...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...
AbstractWe verified the hypothesis that changes in the endogenous GM1 ganglioside density in the env...
We verified the hypothesis that changes in the endogenous GM1 ganglioside density in the environment...
Experimental evidence, both in vitro and in vivo, highlight the neurotrophic and neurodifferentiativ...
Several data suggest a speci\ufb01c role of ganglioside GM1 in neuronal differentiation and developm...
The present study proposes a clarification on the molecular mechanism by which ganglioside GM1 promo...
AbstractThe expression of GABAA receptors in rat cerebellar granules in culture has been studied by ...
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by ac...
The Trk family of protein tyrosine kinases (TrkA/B/C) are receptors for neurotrophins, a family of c...
While Trk receptors can be activated in a neurotrophin-independent manner through “transactivation” ...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...
AbstractNeurotrophins are a group of secreted polypeptides, which comprises Nerve Growth Factor (NGF...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...
AbstractNeurotrophins influence growth and survival of specific populations of neurons through activ...
It has been already demonstrated that the oligosaccharide chain (OligoGM1) of the ganglioside GM1, \...
Discovering the mechanisms underlying homeostatic regulation in brain neural network formation and s...