Chitosan/TPP microparticles obtained by microemulsion method applied in controlled release of heparin

Martins, Alessandro F.
de Oliveira, Daiane M.
Pereira, Antonio G.B.
Rubira, Adley F.
Muniz, Edvani C.

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Publication date

December 2012

DOI

10.1016/j.ijbiomac.2012.08.032

Publisher

Elsevier B.V.

ISSN

0141-8130

Citation count (estimate)

Abstract

AbstractThis work deals with the preparation of chitosan/tripolyphosphate microparticles (CHT/TPP) using microemulsion system based on water/benzyl alcohol. The morphology of the microparticles was evaluated by scanning electron microscopy (SEM). The microparticles were also characterized through infrared spectroscopy (FTIR) and wide-angle X-ray scattering (WAXS). The morphology and crystallinity of microparticles depended mainly on CHT/TPP ratio. Studies of controlled release of HP were evaluated in distilled water and in simulated gastric fluid. Besides, the profile of HP releasing could be tailored by tuning the CHT/TPP molar ratio. Finally, these prospective results allow the particles to be employed as site-specific HP controlled relea...