Fast solute release from photosensitive liposomes: an alternative to ‘caged’ reagents for use in biological systems
- Morgan, Christopher G.
- Bisby, Roger H.
- Johnson, Steven A.
- Mitchell, Andrew C.
Publication date
November 1995
DOI Publisher
Published by Elsevier B.V. ISSN
0014-5793Abstract
AbstractThe kinetics of release of soluble marker trapped in liposomes of gel phase phospholipid containing a photoisomerisable phospholipid analogue have been investigated. Marker release is triggered by UV laser flash photolysis at 355 nm. A markedly temperature-dependent release rate is seen, and above 25°C millisecond release kinetics can be achieved. These results suggest that such liposomes might find application as an alternative to conventional ‘caged’ reagents for photo-triggered reagent release in biological research
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