SummaryGlucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the consequences of insufficient insulin secretion, and is inadequate at low glucose, potentially leading to fatal hypoglycemia. The causal mechanisms remain unknown. Here we show that α cell KATP-channel activity is very low under hypoglycemic conditions and that hyperglycemia, via elevated intracellular ATP/ADP, leads to complete inhibition. This produces membrane depolarization and voltage-dependent inactivation of the Na+ channels involved in action potential firing that, via reduced action potential height and Ca2+ entry, suppresses glucagon secretion. Maneuvers t...
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen ...
Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated ...
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen ...
SummaryGlucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In di...
Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes,...
Closure of ATP-regulated K+ channels (KATP channels) plays a central role in glucose-stimulated insu...
Glucagon secreted by pancreatic α-cells is a hyperglycemic hormone which plays a major role in the c...
OBJECTIVE: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglyce...
AbstractA paradigm for control of insulin secretion is that glucose metabolism elevates cytoplasmic ...
ATP-sensitive potassium channels (K ATP channels) link cell metabolism to electrical activity by con...
OBJECTIVE: The mechanisms by which glucose stimulates insulin secretion from β-cells are well establ...
The mechanisms of glucagon secretion and its suppression by glucose are presently unknown. This stud...
AbstractThe mechanism by which glucose induces insulin secretion in β-cells is fairly well understoo...
SummaryExcessive secretion of glucagon is a major contributor to the development of diabetic hypergl...
Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depen...
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen ...
Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated ...
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen ...
SummaryGlucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In di...
Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes,...
Closure of ATP-regulated K+ channels (KATP channels) plays a central role in glucose-stimulated insu...
Glucagon secreted by pancreatic α-cells is a hyperglycemic hormone which plays a major role in the c...
OBJECTIVE: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglyce...
AbstractA paradigm for control of insulin secretion is that glucose metabolism elevates cytoplasmic ...
ATP-sensitive potassium channels (K ATP channels) link cell metabolism to electrical activity by con...
OBJECTIVE: The mechanisms by which glucose stimulates insulin secretion from β-cells are well establ...
The mechanisms of glucagon secretion and its suppression by glucose are presently unknown. This stud...
AbstractThe mechanism by which glucose induces insulin secretion in β-cells is fairly well understoo...
SummaryExcessive secretion of glucagon is a major contributor to the development of diabetic hypergl...
Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depen...
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen ...
Closure of ATP-regulated K(+) channels (K(ATP) channels) plays a central role in glucose-stimulated ...
Glucagon, secreted from pancreatic islet alpha cells, stimulates gluconeogenesis and liver glycogen ...