Investigation of in vivo neuropharmacological effect of Alpinia nigra leaf extract

Sharmen, Farjana
Mannan, Adnan
Rahman, Md. Mominur
Chowdhury, Md. Ashraf Uddin
Uddin, Muhammad Erfan
Ahmed, A.M. Abu

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Publication date

February 2014

DOI

10.1016/S2221-1691(14)60222-7

Publisher

Hainan Medical University. Production and hosting by Elsevier (Singapore) Pte Ltd.

Abstract

ABSTRACTObjectiveTo analyze in vivo neuro-pharmacological effects of Alpinia nigra as anxiety is a particular form of behavioral inhibition that occurs in response to novel environmental events.MethodsIn present study, the extract of Alpinia nigra was evaluated for its central nervous system depressant effect using mice behavioral models, such as hole cross, open field and thiopental sodium induced sleeping time tests for its sedative properties and an elevated plus-maze test for its anxiolytic potential, respectively.ResultsIn anxiolytic study, the extract displayed increased percentage of entry into open arm at the dose of 400 and 200 mg/kg. The extract produced a significant (P<0.01) increase in sleeping duration and reduction of onset o...