beta-amyloid peptide (A beta) is the primary protein component of senile plaques in Alzheimer's disease patients. Synthetic A beta spontaneously assembles into amyloid fibrils and is neurotoxic to cortical cultures. Neurotoxicity has been associated with the degree of peptide aggregation, yet the mechanism of assembly of A beta into amyloid fibrils is poorly understood. In this work, A beta was dissolved in several different solvents commonly used in neurotoxicity assays. In pure dimethylsulfoxide (DMSO), A beta had no detectable beta-sheet content; in 0.1% trifluoroacetate, the peptide contained one-third beta-sheet; and in 35% acetonitrile/0.1% trifluoroacetate, A beta was two-thirds beta-sheet, equivalent to the fibrillar peptide in phys...
The presence in patient’s brain tissues of neuritic plaques containing Aβ aggregates is one of the p...
AbstractThe aggregation of amyloid-β protein (Aβ) in vivo is a critical pathological event in Alzhei...
Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid casca...
beta-amyloid peptide (A beta) is the major protein component of senile plaques and cerebrovascular a...
One of the clinical manifestations of Alzheimer's disease is the deposition of the 39–43 residue amy...
Beta-Amyloid peptide (A beta) is the major proteinacious constituent of senile plaques in Alzheimer’...
Synthetic amyloid beta-protein (A beta) is used widely to study fibril formation and the physiologic...
The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has bee...
The self-assembly of two derivatives of KLVFF, a fragment Abeta(16-20) of the amyloid beta (Abeta) p...
grantor: University of TorontoIn Alzheimer disease (AD), polymerization of the amyloid ß p...
We provide a validated and rapid protocol for the solubilization of amyloid -peptide (A). This proce...
AbstractExtracellular senile plaques are a central pathological feature of Alzheimer's disease. At t...
The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amylo...
AbstractThe free energy landscape for folding of the Alzheimer’s amyloid-β(25–35) peptide is explore...
Aggregation of amyloid-β (Aβ) peptides is a characteristic pathological feature of Alzheimer\u27s di...
The presence in patient’s brain tissues of neuritic plaques containing Aβ aggregates is one of the p...
AbstractThe aggregation of amyloid-β protein (Aβ) in vivo is a critical pathological event in Alzhei...
Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid casca...
beta-amyloid peptide (A beta) is the major protein component of senile plaques and cerebrovascular a...
One of the clinical manifestations of Alzheimer's disease is the deposition of the 39–43 residue amy...
Beta-Amyloid peptide (A beta) is the major proteinacious constituent of senile plaques in Alzheimer’...
Synthetic amyloid beta-protein (A beta) is used widely to study fibril formation and the physiologic...
The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has bee...
The self-assembly of two derivatives of KLVFF, a fragment Abeta(16-20) of the amyloid beta (Abeta) p...
grantor: University of TorontoIn Alzheimer disease (AD), polymerization of the amyloid ß p...
We provide a validated and rapid protocol for the solubilization of amyloid -peptide (A). This proce...
AbstractExtracellular senile plaques are a central pathological feature of Alzheimer's disease. At t...
The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amylo...
AbstractThe free energy landscape for folding of the Alzheimer’s amyloid-β(25–35) peptide is explore...
Aggregation of amyloid-β (Aβ) peptides is a characteristic pathological feature of Alzheimer\u27s di...
The presence in patient’s brain tissues of neuritic plaques containing Aβ aggregates is one of the p...
AbstractThe aggregation of amyloid-β protein (Aβ) in vivo is a critical pathological event in Alzhei...
Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid casca...