AbstractThe tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20
SummaryIn response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest the c...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
AbstractThe tumour suppressor protein p53 is stabilised and activated in response to ionising radiat...
Our cells are constantly dealing with DNA damage generated by endogenous cellular activity (e.g. DNA...
A functional DNA damage response is essential for maintaining genome integrity in the presence of DN...
SummaryDNA damage induced by ionizing radiation activates the ATM kinase, which subsequently stabili...
The p53 tumor suppressor protein is stabilized in response to ionizing radiation and accumulates in ...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
AbstractBecause DNA damage -inducible cell cycle checkpoints are thought to protect cells from the l...
DNA damage activates checkpoint controls which block progression of cells through the division cycle...
DNA damage activates checkpoint controls which block progression of cells through the division cycle...
The p53 protein acts a tumor suppressor by inducing cell cycle arrest and apoptosis in response to D...
The G2/M checkpoint is important in preventing cells with unrepaired DNA double strand breaks (DSBs)...
SummaryIn response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest the c...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
AbstractThe tumour suppressor protein p53 is stabilised and activated in response to ionising radiat...
Our cells are constantly dealing with DNA damage generated by endogenous cellular activity (e.g. DNA...
A functional DNA damage response is essential for maintaining genome integrity in the presence of DN...
SummaryDNA damage induced by ionizing radiation activates the ATM kinase, which subsequently stabili...
The p53 tumor suppressor protein is stabilized in response to ionizing radiation and accumulates in ...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
The tumor suppressor p53 is a transcriptional regulator whose ability to inhibit cell growth is depe...
AbstractBecause DNA damage -inducible cell cycle checkpoints are thought to protect cells from the l...
DNA damage activates checkpoint controls which block progression of cells through the division cycle...
DNA damage activates checkpoint controls which block progression of cells through the division cycle...
The p53 protein acts a tumor suppressor by inducing cell cycle arrest and apoptosis in response to D...
The G2/M checkpoint is important in preventing cells with unrepaired DNA double strand breaks (DSBs)...
SummaryIn response to DNA damage, eukaryotic cells activate ATM-Chk2 and/or ATR-Chk1 to arrest the c...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the ce...
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