Natural IgE Production in the Absence of MHC Class II Cognate Help
- McCoy, Kathy D.
- Harris, Nicola L.
- Diener, Philipp
- Hatak, Sarah
- Odermatt, Bernhard
- Hangartner, Lars
- Senn, Beatrice M.
- Marsland, Benjamin J.
- Geuking, Markus B.
- Hengartner, Hans
- Macpherson, Andrew J.S.
- Zinkernagel, Rolf M.
DOIAbstract
SummaryIgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals
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