Nuclear receptors bind chromosome ends in “alternative lengthening of telomeres” (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere insertions (TTI)
About 15% of human cancers counteract telomere loss by alternative lengthening of telomeres (ALT), w...
International audienceAs in human cells, yeast telomeres can be maintained in cells lacking telomera...
SummaryThe G-rich single-stranded DNA at the 3′ end of human telomeres can self-fold into G-quaduple...
Nuclear receptors bind chromosome ends in “alternative lengthening of telomeres” (ALT) cancer cells ...
Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of hum...
SummaryThe breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instabili...
Telomere clustering is required for the homologous recombination events that maintain chromosome end...
Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of hum...
The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctio...
SummaryCancer cells rely on the activation of telomerase or the alternative lengthening of telomeres...
Telomeres are DNA-protein complexes that help protecting the end of linear chromosomes. They consist...
About 15% of human cancers counteract telomere loss by alternative lengthening of telomeres (ALT), w...
International audienceAs in human cells, yeast telomeres can be maintained in cells lacking telomera...
SummaryThe G-rich single-stranded DNA at the 3′ end of human telomeres can self-fold into G-quaduple...
Nuclear receptors bind chromosome ends in “alternative lengthening of telomeres” (ALT) cancer cells ...
Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of hum...
SummaryThe breakage-fusion-bridge cycle is a classical mechanism of telomere-driven genome instabili...
Telomere clustering is required for the homologous recombination events that maintain chromosome end...
Telomere length maintenance is a requisite feature of cellular immortalization and a hallmark of hum...
The ends of linear chromosomes are capped by nucleoprotein structures called telomeres. A dysfunctio...
SummaryCancer cells rely on the activation of telomerase or the alternative lengthening of telomeres...
Telomeres are DNA-protein complexes that help protecting the end of linear chromosomes. They consist...
About 15% of human cancers counteract telomere loss by alternative lengthening of telomeres (ALT), w...
International audienceAs in human cells, yeast telomeres can be maintained in cells lacking telomera...
SummaryThe G-rich single-stranded DNA at the 3′ end of human telomeres can self-fold into G-quaduple...