Acute renal failure after Crotalus durissus snakebite: A prospective survey on 100 patients

Acute renal failure after Crotalus durissus snakebite: A prospective survey on 100 patients.BackgroundAcute renal failure (ARF) is the main cause of death after the South American crotalid snakebite. The aim of this study was to assess the prevalence, risk factors, and characteristics of Crotalusdurissus venom-induced ARF.MethodsOne hundred cases of Crotalusdurissus bite were studied from hospitalization to discharge or death. Creatinine clearance (GFR) <60 mL/min/1.73m2 in the first 72 hours after snakebite was defined as ARF. Data are expressed as median (range of variation) or%, and were analyzed by univariate analysis and logistic regression.ResultsTwenty-nine patients developed ARF. Of those, 24% required dialysis and 10% died. ARF patients had smaller body surface [1.55 (0.6–2.3) vs. 1.7 (0.6–2.1) m2, P = 0.0097], received antivenom (AV) later [12 (2–48) vs. 2 (1–14) hours, P < 0.0001], received more AV [190 (90–536) vs. 158 (75–500)mg/m2, P < 0.0001], presented lower diuresis at admission [62 (0–182) mL/hr vs. 100 (25–325) mL/hr, P = 0.0004], and showed a striking creatine kinase (CK) increase [50,250 (69–424,120) vs. 1108 (88–133,170) U/L, P < 0.0001]. Age <12 years (OR 5.6, P = 0.026), time for AV >2 hours (OR 11.1, P = 0.032), CK at admission >2000 U/L (OR 12.7, P = 0.0009) were identified as independent risk factors for ARF, whereas diuresis at admission >90 mL/hr (OR 0.20, P = 0.014) was an independent protector factor.ConclusionC. durissus venom-induced ARF had high prevalence (29%). Delay for AV treatment, CK at admission >2000 U/L, and age <12 years were independent risk factors for ARF development. Diuresis at admission >90 mL/hr was a protective factor