Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
- Jones, Gregory T.
- Tromp, Gerard
- Kuivaniemi, Helena
- Gretarsdottir, Solveig
- Baas, Annette F.
- Giusti, Betti
- Strauss, Ewa
- van't Hof, Femke N. G.
- Webb, Thomas R.
- Erdman, Robert
- Ritchie, Marylyn D.
- Elmore, James R.
- Verma, Anurag
- Pendergrass, Sarah
- Kullo, Iftikhar J.
- Zy, Zi Ye
- Peissig, Peggy L.
- Gottesman, Omri
- Verma, Shefali S.
- Malinowski, Jennifer
- Rasmussen-Torvik, Laura J.
- Borthwick, Kenneth M.
- Smelser, Diane T.
- Crosslin, David R.
- de Andrade, Mariza
- Ryer, Evan J.
- McCarty, Catherine A.
- Bottinger, Erwin P.
- Pacheco, Jennifer A.
- Crawford, Dana C.
- Carrell, David S.
- Gerhard, Glenn S.
- Franklin, David P.
- Carey, David J.
- Phillips, Victoria L.
- Williams, Michael J. A.
- Wei, Wenhua
- Blair, Ross
- Hill, Andrew A.
- Vasudevan, Thodor M.
- Lewis, David R.
- Thomson, Ian A.
- Krysa, Jo
- Hill, Geraldine B.
- Roake, Justin
- Merriman, Tony R.
- Oszkinis, Grzegorz
- Galora, Silvia
- Saracini, Claudia
- Abbate, Rosanna
- Pulli, Raffaele
- Pratesi, Carlo
- Saratzis, Athanasios
- Verissimo, Ana R.
- Bumpstead, Suzannah
- Badger, Stephen A.
- Clough, Rachel E.
- Cockerill, Gillian
- Hafez, Hany
- Scott, D. Julian A.
- Futers, T. Simon
- Romaine, Simon P. R.
- Bridge, Katherine
- Griffin, Kathryn J.
- Bailey, Marc A.
- Smith, Alberto
- Thompson, Matthew M.
- van Bockxmeer, Frank M.
- Matthiasson, Stefan E.
- Thorleifsson, Gudmar
- Thorsteinsdottir, Unnur
- Blankensteijn, Jan D.
- Teijink, Joep A. W.
- Wijmenga, Cisca
- de Graaf, Jacqueline
- Kiemeney, Lambertus A.
- Lindholt, Jes S.
- Hughes, Anne
- Bradley, Declan T.
- Stirrups, Kathleen
- Golledge, Jonathan
- Norman, Paul E.
- Powell, Janet T.
- Humphries, Steve E.
- Hamby, Stephen E.
- Goodall, Alison H.
- Nelson, Christopher P.
- Sakalihasan, Natzi
- Courtois, Audrey
- Ferrell, Robert E.
- Eriksson, Per
- Folkersen, Lasse
- Franco-Cereceda, Anders
- Eicher, John D.
- Johnson, Andrew D.
- Betsholtz, Christer
- Ruusalepp, Arno
- Franzen, Oscar
- Schadt, Eric E.
- Bjorkegren, Johan L. M.
- Lipovich, Leonard
- Drolet, Anne M.
- Verhoeven, Eric L.
- Zeebregts, Clark J.
- Geelkerken, Robert H.
- van Sambeek, Marc R.
- van Sterkenburg, Steven M.
- de Vries, Jean-Paul
- Stefansson, Kari
- Thompson, John R.
- de Bakker, Paul I. W.
- Deloukas, Panos
- Sayers, Robert D.
- Harrison, Seamus C.
- van Rij, Andre M.
- Samani, Nilesh J.
- Bown, Matthew J.
DOIAbstract
Rationale: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. Objective: To identify additional AAA risk loci using data from all available genome-wide association studies. Methods and Results: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery di...
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