During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between thos...
Cell shape and motility are primarily controlled by cellular mechanics. The attachment of the plasma...
Understanding the factors that direct tissue organization during development is one of the most fund...
During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and inter...
During embryonic development, mechanical forces are essential for cellular rearrangements driving ti...
AbstractEmbryonic morphogenesis takes place via a series of dramatic collective cell movements. The ...
Interstitial fluid (IF) accumulation between embryonic cells is thought to be important for embryo p...
Cell movements are coordinated across spatio-temporal scales to achieve precise positioning of organ...
Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkabl...
Developmental biologists try to elucidate how it is possible for cells, all originating from the sam...
Gastrulation leads to the formation of the embryonic germ layers, ectoderm, mesoderm and endoderm, a...
Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkabl...
Embryonic development is a complicated phenomenon influenced by genetic regulation and biomechanical...
The developmental strategies used by progenitor cells to endure a safe journey from their induction ...
During animal embryogenesis, homeostasis and disease, tissues push and pull on their surroundings to...
Embryonic development involves the cellular integration of chemical and physical stimuli. A key phys...
Cell shape and motility are primarily controlled by cellular mechanics. The attachment of the plasma...
Understanding the factors that direct tissue organization during development is one of the most fund...
During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and inter...
During embryonic development, mechanical forces are essential for cellular rearrangements driving ti...
AbstractEmbryonic morphogenesis takes place via a series of dramatic collective cell movements. The ...
Interstitial fluid (IF) accumulation between embryonic cells is thought to be important for embryo p...
Cell movements are coordinated across spatio-temporal scales to achieve precise positioning of organ...
Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkabl...
Developmental biologists try to elucidate how it is possible for cells, all originating from the sam...
Gastrulation leads to the formation of the embryonic germ layers, ectoderm, mesoderm and endoderm, a...
Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkabl...
Embryonic development is a complicated phenomenon influenced by genetic regulation and biomechanical...
The developmental strategies used by progenitor cells to endure a safe journey from their induction ...
During animal embryogenesis, homeostasis and disease, tissues push and pull on their surroundings to...
Embryonic development involves the cellular integration of chemical and physical stimuli. A key phys...
Cell shape and motility are primarily controlled by cellular mechanics. The attachment of the plasma...
Understanding the factors that direct tissue organization during development is one of the most fund...
During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and inter...