T-cell specificity is determined by the T-cell receptor, a heterodimeric protein coded for by an extremely diverse set of genes produced by imprecise somatic gene recombination. Massively parallel high-throughput sequencing allows millions of different T-cell receptor genes to be characterized from a single sample of blood or tissue. However, the extraordinary heterogeneity of the immune repertoire poses significant challenges for subsequent analysis of the data. We outline the major steps in processing of repertoire data, considering low-level processing of raw sequence files and high-level algorithms, which seek to extract biological or pathological information. The latest generation of bioinformatics tools allows millions of DNA sequence...
The immune system is a dynamic feature of each individual and a footprint of our unique internal and...
The diversity of antigen receptors and the specificity it underlies are the hallmarks of the cellula...
Thesis (Ph.D.)--University of Washington, 2018B and T lymphocytes are the cellular effectors of the ...
The adaptive immune systems of jawed vertebrates are based upon lymphocytes bearing a huge variety o...
Over the last few years, there has been a rapid expansion in the application of information technolo...
Maintaining a diverse immune repertoire is crucial for protection against a wide range of pathogens....
The diversity of the immunological repertoire has long been a subject of research focus, providing i...
The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated ...
T cell receptor (TCR) is a heterodimer consisting of TCR alpha and TCR beta chains that are generate...
The T cell receptor (TCR) repertoire can be regarded as an example of a high-dimensional and persona...
The T cell receptor (TCR) repertoire can provide a personalized biomarker for infectious and non-inf...
The T cell receptor (TCR) repertoire has the potential to be a highly personalised biomarker of his...
Recent advances in high throughput sequencing (HTS) of T cell receptors (TCRs) and in transcriptomic...
The T cell receptor (TCR) repertoire can provide a personalized biomarker for infectious and non-inf...
Background Deep-sequencing methods are rapidly developing in the field of B-cell receptor (BCR) and ...
The immune system is a dynamic feature of each individual and a footprint of our unique internal and...
The diversity of antigen receptors and the specificity it underlies are the hallmarks of the cellula...
Thesis (Ph.D.)--University of Washington, 2018B and T lymphocytes are the cellular effectors of the ...
The adaptive immune systems of jawed vertebrates are based upon lymphocytes bearing a huge variety o...
Over the last few years, there has been a rapid expansion in the application of information technolo...
Maintaining a diverse immune repertoire is crucial for protection against a wide range of pathogens....
The diversity of the immunological repertoire has long been a subject of research focus, providing i...
The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated ...
T cell receptor (TCR) is a heterodimer consisting of TCR alpha and TCR beta chains that are generate...
The T cell receptor (TCR) repertoire can be regarded as an example of a high-dimensional and persona...
The T cell receptor (TCR) repertoire can provide a personalized biomarker for infectious and non-inf...
The T cell receptor (TCR) repertoire has the potential to be a highly personalised biomarker of his...
Recent advances in high throughput sequencing (HTS) of T cell receptors (TCRs) and in transcriptomic...
The T cell receptor (TCR) repertoire can provide a personalized biomarker for infectious and non-inf...
Background Deep-sequencing methods are rapidly developing in the field of B-cell receptor (BCR) and ...
The immune system is a dynamic feature of each individual and a footprint of our unique internal and...
The diversity of antigen receptors and the specificity it underlies are the hallmarks of the cellula...
Thesis (Ph.D.)--University of Washington, 2018B and T lymphocytes are the cellular effectors of the ...