Glycogen, a branched polymer of glucose, is well known as a cellular reserve of metabolic energy and/or biosynthetic precursors. Besides glucose, however, glycogen contains small amounts of covalent phosphate, present as C2 and C3 phosphomonoesters. Current evidence suggests that the phosphate is introduced by the biosynthetic enzyme glycogen synthase as a rare alternative to its normal catalytic addition of glucose units. The phosphate can be removed by the laforin phosphatase, whose mutation causes a fatal myoclonus epilepsy called Lafora disease. The hypothesis is that glycogen phosphorylation can be considered a catalytic error and laforin a repair enzyme
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structur...
Enzymes of intermediary metabolism are considered as very specific. However, most of them show weak ...
Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as sev...
AbstractGlycogen, a branched polymer of glucose, is well known as a cellular reserve of metabolic en...
SummaryGlycogen is a branched polymer of glucose that serves as an energy store. Phosphate, a trace ...
The storage polymer glycogen normally contains small amounts of covalently attached phosphate as pho...
Phosphorylation of glycogen has been known for decades; however, the basic metabolic pathways respon...
Indiana University-Purdue University Indianapolis (IUPUI)Glycogen is a highly branched polymer of gl...
Covalent phosphorylation of glycogen, first described 35 years ago, was put on firm ground through t...
SummaryLaforin or malin deficiency causes Lafora disease, characterized by altered glycogen metaboli...
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycoge...
Glycogen, the repository of glucose in many cell types, contains small amounts of covalent phosphate...
Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycog...
The polysaccharide molecule glycogen represents a crucial glucose (and hence energy) storage reserve...
12 p.-7 fig. Nitschke, Felix et al.Lafora disease (LD) is a fatal progressive epilepsy essentially ...
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structur...
Enzymes of intermediary metabolism are considered as very specific. However, most of them show weak ...
Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as sev...
AbstractGlycogen, a branched polymer of glucose, is well known as a cellular reserve of metabolic en...
SummaryGlycogen is a branched polymer of glucose that serves as an energy store. Phosphate, a trace ...
The storage polymer glycogen normally contains small amounts of covalently attached phosphate as pho...
Phosphorylation of glycogen has been known for decades; however, the basic metabolic pathways respon...
Indiana University-Purdue University Indianapolis (IUPUI)Glycogen is a highly branched polymer of gl...
Covalent phosphorylation of glycogen, first described 35 years ago, was put on firm ground through t...
SummaryLaforin or malin deficiency causes Lafora disease, characterized by altered glycogen metaboli...
Glycogen is a branched polymer of glucose that acts as an energy reserve in many cell types. Glycoge...
Glycogen, the repository of glucose in many cell types, contains small amounts of covalent phosphate...
Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycog...
The polysaccharide molecule glycogen represents a crucial glucose (and hence energy) storage reserve...
12 p.-7 fig. Nitschke, Felix et al.Lafora disease (LD) is a fatal progressive epilepsy essentially ...
Glycogen is the major glucose reserve in eukaryotes, and defects in glycogen metabolism and structur...
Enzymes of intermediary metabolism are considered as very specific. However, most of them show weak ...
Lafora disease (LD) is a fatal, autosomal recessive, glycogen-storage disorder that manifests as sev...