Screening for pain phenotypes: Analysis of three congenic mouse strains on a battery of nine nociceptive assays

In an attempt to identify new genes responsible for variability in pain sensitivity, we tested three congenic mouse strains – in which a small portion of the genome of the MOLF/Ei strain has been placed on a C57BL/6 genetic background – on a battery of nine nociceptive assays, chosen to reflect those assays in most common use in the pain literature. Mice of both sexes were evaluated by two different testers at different points in time, allowing us to examine the relative importance of genotype, sex, tester and cohort effects on data from these assays [...