Lead in cerebrospinal fluid in clinical lead poisoning

Izvršena su određivanja koncentracije olova u likvoru kod 43 bolesnika. Oni su bili izloženi parama i prašini olovnih oksida (grupa I - 15 bolesnika), parama olovnog tetraetila (grupa III - 15 bolesnika), a kod 13 bolesnika do otrovanja je došlo zbog upotrebe zemljanog posuđa glaziranog olovnom gleđi (grupa II). Paralelno je određivana koncentracija olova kontrolnoj grupi od 10 ispitanika, koji nisu bili u poznatoj ekspoziciji olovu. Rezultati su pokazali, da su u prosjeku koncentracije olova u likvoru kod eksponiranih ispitanika više od istih kod kontrolne grupe. Rasponi koncentracija bili su ovi: za grupu I 0-82, za grupu II 0-104, za grupu III 0-40, a za ispitanike kontrolne grupe 0-18 µg Pb/100 ml likvora. lako nije uvijek bilo korelacije između koncentracije olova u likvoru i kliničkih kao i drugih znakova otrovanja, značajno je da kod otrovanja olovom može doći do povećane koncentracije olova u likvoru.The analysis of the cerebrospinal fluid lead concentration was performed in 43 patients exposed to lead oxide dust (Group I - 15 patients), lead tetraethyl (Group III - 15 patients), and using lead-glazed pottery (Group II - 13 patients). A group of 10 persons with no known exposure to lead was examined, in the same way and served as - controls. The results have shown that on the average the fluid lead concentrations in the exposed persons were higher than in the control group. The concentrations ranged from 0-82 in Group I, from 0-104 in Group II, from 0-40 in Group III, and from 0-18 µg Pb/100 ml fluid in the control group. Although the cerebrospinal fluid lead concentrations were not always correlated with clinical and other signs of poisoning, it is worth noting that an increased fluid lead concentration in lead poisoning is possible