Toksični učinci dvaju karbamatnih insekticida na psima

In workers exposed to propoxur (2-isopropoxyphenyl methylcarbamate) and promecarb (3-methyl-5-isopropylphenyl methyl carbamate) the duration of plasma cholinesterase inhibition significantly differs. The aim of the present work was to find out whether this is due to differences related to enzyme-inhibitor interaction or to differences in insecticide absorption. Approximate equitoxic doses of the two carbamates were injected to dogs intravenously and intramuscularly. The intensity and quality of cholinergic symptoms were recorded and plasma cholinesterase activity measured at given time intervals. While the differences were found only after intramuscular application, the enzyme activity recovery was similar for both carbamates injected intravenously. The delayed plasma cholinesterase recovery in the case of promecarb could be explained by a much slower absorption after intramuscular injection of the compound.U radnika eksponiranih propoksuru (2-izopropoksifenil N-metil karbamat) i promekarbu (3-metil-5-izopropoksifenil N-metil karbamat) nađene su razlike u trajanju inhibicije kolinesteraze plazme. Svrha ovog rada bila je utvrditi da li ova pojava počiva na razlikama u interakciji otrova s enzimom ili pak na različitim načinima ulaska otrova u organizam. Pokusi su rađeni na psima križancima kojima smo približno ekvitoksične doze istraživanih spojeva injicirali intravenski odnosno intramuskularno. Pratili smo i registrirali intenzitet i vrstu kolinergičnih simptoma i u zadanim vremenima mjerili aktivnost kolinesteraze plazme. S obzirom da smo razlike našli samo nakon intramuskularne aplikacije, a da je nakon intravenske aplikacije oporavak enzimske aktivnosti bio za oba spoja podjednak, dugotrajna inhibicija kolinesteraze plazme nakon promekarba može se tumačiti sporijom resorpcijom ovoga spoja pri intramuskularnoj aplikaciji