Treatment of nonalcoholic fatty liver disease

Nealkoholna masna bolest jetre (engl. nonalcoholic fatty liver disease; NAFLD) najčešća je kronična bolest jetre danas. Jedna je od manifestacija metaboličkog sindroma, uz dijabetes, inzulinsku rezistenciju, debljinu, hiperlipidemiju i hipertenziju. NAFLD je klinički sindrom koji obuhvaća jednostavnu steatozu, nealkoholni steatohepatitis, fibrozu i cirozu jetre te hepatocelularni karcinom. Za sada ne postoji optimalna terapija nealkoholne masne bolesti jetre, liječenje se temelji na promjeni načina života, dijeti i tjelesnoj aktivnosti. Lijekovi za smanjenje inzulinske rezistencije, vitamini E i D te blokatori renin-angiotenzinaldosteron sustava pokazuju obećavajuće rezultate u pristupu pacijentu s NAFLD-om, ali njihova dugoročna učinkovitost i sigurnost primjene još uvijek nije znanstveno utemeljena.Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide. NAFLD is a liver manifestation of metabolic syndrome, along with hypertension, diabetes, dyslipidemia and insulin resistance. Nonalcoholic steatohepatitis (NASH) is a progressive form of NAFLD, which often develops into liver cirrhosis and increases the risk of hepatocellular carcinoma. There is no optimal treatment for NAFLD and most treatment options are based on lifestyle changes, diet and physical activity. Medications that are reducing insulin resistance, vitamin E and D and renin-angiotensin-aldosterone system blockers have shown promising results, but their long-term effectiveness and safety remains to be established