Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
- Krause, Lutz
- Nones, Katia
- Loffler, Kelly A
- Nancarrow, Derek J
- Oey, Harald
- Tang, Yue Hang
- Wayte, Nicci
- Patch, Ann-Marie
- Patel, Kalpana
- Thomas, Janine
- Stoye, Jens
- Hussey, Damian James
- Watson, David Ian
- Lord, Reginald V
- Phillips, Wayne A
- Gotley, David C
- Smithers, B Mark
- Whiteman, David C
- Hayward, Nicholas K
- Grimmond, Sean M
- Waddell, Nicola
- Barbour, Andrew P
DOIAbstract
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.comThe incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure rates remain poor, with <20% of patients surviving 5 years. This is the first study to explore methylome, transcriptome and ENCODE data to characterize the role of methylation in EAC. We investigate the genome-wide methylation profile of 250 samples includ...
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