Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, which involves progressive motor neuron degeneration in the central nervous system (CNS). The G93A SOD1 mouse model simulates one of the most common causes of familial ALS through the overexpression of a mutated form of the human gene encoding copper/zinc superoxide dismutase (SOD1). Transition metals, particularly Cu and Zn, have been shown to behave abnormally in the disease context and have been hypothesized to contribute to and potentially trigger the disease. In this study, concentrations of Cu, Zn and Fe, as well as Cu isotope ratios were assessed in keystone tissues of ALS, including the brain, spinal cord, muscle and whole blood, from transgenic mutant SOD1G93A mice and ...
Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familia...
Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is re...
This is the publisher’s final pdf. The published article is copyrighted by the author(s) and publish...
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, which involves progressive motor neur...
© 2018 Elsevier Inc. Background: Amyotrophic lateral sclerosis (ALS) is among the most common of the...
Background: Amyotrophic lateral sclerosis (ALS) is among the most common of the motor neuron disease...
© 2019 The Royal Society of Chemistry. Mutations in the copper (Cu)- and zinc (Zn)-binding metalloen...
Modulations of the potentially toxic transition metals iron (Fe) and copper (Cu) are implicated in t...
Summary: Redox-active metals are thought to be implicated in neurodegenerative diseases including am...
Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral scleros...
Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-...
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by a loss of ...
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by a loss of ...
© 2016 Dr. James Benjamin William HiltonAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenera...
A large body of evidence indicates that abnormalities in the levels of iron, copper and zinc and the...
Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familia...
Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is re...
This is the publisher’s final pdf. The published article is copyrighted by the author(s) and publish...
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, which involves progressive motor neur...
© 2018 Elsevier Inc. Background: Amyotrophic lateral sclerosis (ALS) is among the most common of the...
Background: Amyotrophic lateral sclerosis (ALS) is among the most common of the motor neuron disease...
© 2019 The Royal Society of Chemistry. Mutations in the copper (Cu)- and zinc (Zn)-binding metalloen...
Modulations of the potentially toxic transition metals iron (Fe) and copper (Cu) are implicated in t...
Summary: Redox-active metals are thought to be implicated in neurodegenerative diseases including am...
Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral scleros...
Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-...
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by a loss of ...
Amyotrophic lateral sclerosis is a progressive neurodegenerative disease characterized by a loss of ...
© 2016 Dr. James Benjamin William HiltonAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenera...
A large body of evidence indicates that abnormalities in the levels of iron, copper and zinc and the...
Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familia...
Disrupted metal homeostasis is a consistent feature of neurodegenerative disease in humans and is re...
This is the publisher’s final pdf. The published article is copyrighted by the author(s) and publish...