Platelet activating factor receptor blockade ameliorates murine systemic lupus erythematosus. Untreated 16-week-old MRL/MpJ-lpr/lpr (lpr) mice, when compared to congenic MRL/MpJ-+/+ (+/+) mice, are characterized by a systemic lupus erythematosus syndrome, including severe glomerulonephritis, proteinuria and reduction of renal function. We hypothesized that platelet activating factor (PAF), a potent chemotactic and proinflammatory phospholipid mediator synthesized and released by circulating cells, glomerular mesangial and renal medullary interstitial cells, may play a role in the development of renal injury in lupus mice. We assessed renal PAF synthesis in lpr as well as +/+ mice and the effect of treatment with a PAF receptor blocking agen...
Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. O...
Modulation of renal disease in MRL/ lpr mice by pharmacologic inhibition of inducible nitric oxide s...
Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic...
Platelet activating factor receptor blockade ameliorates murine systemic lupus erythematosus. Untrea...
Platelet activating factor (PAF) as a mediator of injury in nephrotic nephritis. Release of acetyl g...
Women with systemic lupus erythematosus exhibit a high prevalence of hypertension, endothelial dysfu...
Platelet activating factor (PAF) as a mediator of injury in nephrotic nephritis. Release of acetyl g...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...
Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Clas...
Urinary excretion of platelet activating factor in patients with immune-mediated glomerulonephritis....
The renal glomerulus and its various cell types (i.e. mesangial cells, endothelial cells) have been ...
Thromboxane receptor blockade reduces renal injury in murine lupus nephritis. To investigate the rol...
The renal glomerulus and its various cell types (i.e. mesangial cells, endothelial cells) have been ...
The renal glomerulus and its various cell types (i.e. mesangial cells, endothelial cells) have been ...
Abstract Background The purpose of this study was to ...
Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. O...
Modulation of renal disease in MRL/ lpr mice by pharmacologic inhibition of inducible nitric oxide s...
Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic...
Platelet activating factor receptor blockade ameliorates murine systemic lupus erythematosus. Untrea...
Platelet activating factor (PAF) as a mediator of injury in nephrotic nephritis. Release of acetyl g...
Women with systemic lupus erythematosus exhibit a high prevalence of hypertension, endothelial dysfu...
Platelet activating factor (PAF) as a mediator of injury in nephrotic nephritis. Release of acetyl g...
Platelet-derived growth factor (PDGF) has been proved to play an important role in progressive glome...
Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease. Clas...
Urinary excretion of platelet activating factor in patients with immune-mediated glomerulonephritis....
The renal glomerulus and its various cell types (i.e. mesangial cells, endothelial cells) have been ...
Thromboxane receptor blockade reduces renal injury in murine lupus nephritis. To investigate the rol...
The renal glomerulus and its various cell types (i.e. mesangial cells, endothelial cells) have been ...
The renal glomerulus and its various cell types (i.e. mesangial cells, endothelial cells) have been ...
Abstract Background The purpose of this study was to ...
Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. O...
Modulation of renal disease in MRL/ lpr mice by pharmacologic inhibition of inducible nitric oxide s...
Systemic lupus erythematosus is a polymorphic and multigenic inflammatory autoimmune disease. Cyclic...