SummaryTo understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we created induced pluripotent stem cells (iPSCs) from patients carrying the GRNIVS1+5G > C mutation (FTD-iPSCs). FTD-iPSCs were fated to cortical neurons, the cells most affected in FTD. Although generation of neuroprogenitors was unaffected, their further differentiation into CTIP2-, FOXP2-, or TBR1-TUJ1 double-positive cortical neurons, but not motorneurons, was significantly decreased in FTD-neural progeny. Zinc finger nuclease-mediated introduction of GRN cDNA into the AAVS1 locus corrected defects in cortical neurogenesis, demonstrating that PGRN haploinsufficiency causes inefficient cortical neuron generation. RNA sequencing analys...
: Loss-of-function mutations in the progranulin (PGRN) gene are a common cause of familial frontotem...
Frontotemporal dementia (FTD) is a devastating and progressive disorder and a common form of early-o...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...
peer reviewedTo understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dement...
SummaryTo understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FT...
To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we ...
To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we ...
Different types of dementias such as frontotemporal lobar degeneration (FLTD) affect 44.4 millions o...
The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generat...
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and lang...
The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generat...
SummaryProgranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in the CN...
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently spora...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has rema...
: Loss-of-function mutations in the progranulin (PGRN) gene are a common cause of familial frontotem...
Frontotemporal dementia (FTD) is a devastating and progressive disorder and a common form of early-o...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...
peer reviewedTo understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dement...
SummaryTo understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FT...
To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we ...
To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we ...
Different types of dementias such as frontotemporal lobar degeneration (FLTD) affect 44.4 millions o...
The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generat...
Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral changes and lang...
The pathogenic mechanisms of frontotemporal dementia (FTD) remain poorly understood. Here we generat...
SummaryProgranulin (GRN) mutations cause frontotemporal dementia (FTD), but GRN's function in the CN...
Recently, mutations in the progranulin (PGRN) gene were found to cause familial and apparently spora...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has rema...
: Loss-of-function mutations in the progranulin (PGRN) gene are a common cause of familial frontotem...
Frontotemporal dementia (FTD) is a devastating and progressive disorder and a common form of early-o...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...