Analgetic Activity of Papaya (Carica papaya L.) Leaves Extract
- Hasimun, P.
- Suwendar,
- Ernasari, G.I.
Publication date
December 2014
DOI Publisher
The Authors. Published by Elsevier B.V. ISSN
1876-6196 Citation count (estimate)
3Abstract
AbstractThe analgetic activity of Carica papaya leaves (CPL) extracts (n-hexane, ethyl acetate, ethanol) was investigated in mice model using acetic acid induced pain (Siegmund method). Experimental animals were divided into 11 groups and received n-hexane, ethyl acetate, and ethanol extracts at doses of 0.175, 0.35, 0.70mg/kg bw orally; CMC-Na 0.5% (control group); 50 mg/ kg bw of aspirin. The results showed that all extracts at the doses of 0.175, 0.35 and 0.70mg/kg bw gave significant analgetic activity (p<0.05) compared to control group. Ethanol extract of CPL dose of 0.70mg/kg bw showed the best analgetic activity that was comparable to aspirin
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