Challenges for the effective molecular imprinting of proteins
- Verheyen, Ellen
- Schillemans, Joris P.
- van Wijk, Martin
- Demeniex, Marie-Astrid
- Hennink, Wim E.
- van Nostrum, Cornelus F.
DOIAbstract
AbstractMolecular imprinting is a technique that is used to create artificial receptors by the formation of a polymer network around a template molecule. This technique has proven to be particularly effective for molecules with low molecular weight (<1500 Da), and during the past five years the number of research articles on the imprinting of larger (bio)templates is increasing considerably. However, expanding the methodology toward imprinted materials for selective recognition of proteins, DNA, viruses and bacteria appears to be extremely challenging. This paper presents a critical analysis of data presented by several authors and our own experiments, showing that the molecular imprinting of proteins still faces some fundamental challenges...
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