AbstractType I interferons (IFNα/β) are an important part of innate immunity to viral infections because they induce an antiviral response and limit viral replication until the adaptive response clears the infection. Since the nonstructural proteins of several paramyxoviruses inhibit the IFNα/β response, we chose to explore the role of the C protein of measles virus (MV) in such inhibition. Previous studies have suggested that the MV C protein may serve as a virulence factor, but its role in the pathogenesis of MV remains undefined. In the present study, a recombinant MV strain that does not express the C protein (MV C−) and its parental strain (Ed Tag) were used. Growth of MV C− was restricted in human peripheral blood mononuclear cells an...
During a viral infection, when the virus enters into the cytoplasm, different cell types are able to...
AbstractViruses have evolved various strategies to escape the antiviral activity of type I interfero...
AbstractMeasles virus (MV) causes various responses including the induction of immune responses, tra...
AbstractType I interferons (IFNα/β) are an important part of innate immunity to viral infections bec...
AbstractThe C and V proteins of the measles virus (MV) have been shown to block the signaling of typ...
AbstractMeasles virus (MV) belongs to the genus Morbillivirus of the family Paramyxoviridae. A numbe...
AbstractMeasles virus (MV), a member of the family Paramyxoviridae, encodes C and V non-structural p...
AbstractMeasles virus (MeV) produces two accessory proteins, V and C, from the P gene. These accesso...
AbstractParamyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. T...
AbstractTo establish infections, viruses use various strategies to suppress the host defense mechani...
AbstractThe innate immune response, in particular the production of type 1 interferons, is an essent...
The measles virus P gene products V and C antagonize the host interferon (IFN) response, blocking bo...
AbstractIn this article we show that the paramyxovirus SV5 is a poor inducer of interferon-β (IFN-β)...
AbstractThe V protein of measles virus (MV-V) is a potent inhibitor of IFN-α/β signaling pathway. We...
SummaryUnderstanding, treating, and preventing diseases caused by immunosuppression and/or persisten...
During a viral infection, when the virus enters into the cytoplasm, different cell types are able to...
AbstractViruses have evolved various strategies to escape the antiviral activity of type I interfero...
AbstractMeasles virus (MV) causes various responses including the induction of immune responses, tra...
AbstractType I interferons (IFNα/β) are an important part of innate immunity to viral infections bec...
AbstractThe C and V proteins of the measles virus (MV) have been shown to block the signaling of typ...
AbstractMeasles virus (MV) belongs to the genus Morbillivirus of the family Paramyxoviridae. A numbe...
AbstractMeasles virus (MV), a member of the family Paramyxoviridae, encodes C and V non-structural p...
AbstractMeasles virus (MeV) produces two accessory proteins, V and C, from the P gene. These accesso...
AbstractParamyxovirus C protein targets the host interferon (IFN) system for virus immune evasion. T...
AbstractTo establish infections, viruses use various strategies to suppress the host defense mechani...
AbstractThe innate immune response, in particular the production of type 1 interferons, is an essent...
The measles virus P gene products V and C antagonize the host interferon (IFN) response, blocking bo...
AbstractIn this article we show that the paramyxovirus SV5 is a poor inducer of interferon-β (IFN-β)...
AbstractThe V protein of measles virus (MV-V) is a potent inhibitor of IFN-α/β signaling pathway. We...
SummaryUnderstanding, treating, and preventing diseases caused by immunosuppression and/or persisten...
During a viral infection, when the virus enters into the cytoplasm, different cell types are able to...
AbstractViruses have evolved various strategies to escape the antiviral activity of type I interfero...
AbstractMeasles virus (MV) causes various responses including the induction of immune responses, tra...