AbstractAging causes anatomical and functional changes in visual and circadian systems. In wild type mice rods, cones, and photosensitive retinal ganglion cells (pRGCs) decline with age. In rd/rd cl mice, the early loss of rods and cones is followed by protracted transneuronal loss of inner retinal neurons as well as the pRGCs. Here we use Fos induction to study the light input pathway to the suprachiasmatic nuclei (SCN), the intergeniculate leaflets (IGL) and ventral lateral geniculate nuclei (vLGN) of old (∼700 days) and young (∼150 days) wild type and rd/rd cl mice. Cholera toxin tracing was used in parallel to study the anatomy of this pathway. We find that aging rather than retinal degeneration is a more important factor in reducing li...
The behavioral consequences of age-related alterations in neural function are well documented, but l...
AbstractBright light suppresses locomotor activity in mice (negative masking) but dim light augments...
Abstract Background In mammals, the brain clock responsible for generating circadian rhythms is loca...
Aging causes anatomical and functional changes in visual and circadian systems. In wild type mice ro...
AbstractAging causes anatomical and functional changes in visual and circadian systems. In wild type...
Aging causes anatomical and functional changes in visual and circadian systems. In wild type mice ro...
Non-rod, non-cone ocular photoreceptors have been shown to mediate a range of irradiance detection t...
PURPOSE: Following on from reports of retrograde retinal signaling in mice, we sought to investigate...
Robust physiological circadian rhythms form an integral part of well-being. The aging process has be...
The mammalian retina contains an autonomous circadian clock system that controls many physiological ...
The melanopsin system consists of intrinsically photosensitive retinal ganglion cells containing the...
Retinal melatonin is involved in the modulation of many important retinal functions. Our previous st...
Robust physiological circadian rhythms form an integral part of wellbeing. The aging process has be...
The circadian clock is synchronized to the 24 h day by environmental light which is transmitted from...
Circadian timing systems, like most physiological processes, cannot escape the effects of aging. Wit...
The behavioral consequences of age-related alterations in neural function are well documented, but l...
AbstractBright light suppresses locomotor activity in mice (negative masking) but dim light augments...
Abstract Background In mammals, the brain clock responsible for generating circadian rhythms is loca...
Aging causes anatomical and functional changes in visual and circadian systems. In wild type mice ro...
AbstractAging causes anatomical and functional changes in visual and circadian systems. In wild type...
Aging causes anatomical and functional changes in visual and circadian systems. In wild type mice ro...
Non-rod, non-cone ocular photoreceptors have been shown to mediate a range of irradiance detection t...
PURPOSE: Following on from reports of retrograde retinal signaling in mice, we sought to investigate...
Robust physiological circadian rhythms form an integral part of well-being. The aging process has be...
The mammalian retina contains an autonomous circadian clock system that controls many physiological ...
The melanopsin system consists of intrinsically photosensitive retinal ganglion cells containing the...
Retinal melatonin is involved in the modulation of many important retinal functions. Our previous st...
Robust physiological circadian rhythms form an integral part of wellbeing. The aging process has be...
The circadian clock is synchronized to the 24 h day by environmental light which is transmitted from...
Circadian timing systems, like most physiological processes, cannot escape the effects of aging. Wit...
The behavioral consequences of age-related alterations in neural function are well documented, but l...
AbstractBright light suppresses locomotor activity in mice (negative masking) but dim light augments...
Abstract Background In mammals, the brain clock responsible for generating circadian rhythms is loca...