Hereditary mtDNA Heteroplasmy: A Baseline for Aging?
- Keogh, Michael
- Chinnery, Patrick F.
Publication date
October 2013
DOI Publisher
Elsevier Inc. ISSN
1550-4131 Citation count (estimate)
13Abstract
Do mtDNA mutations contribute to the aging process, or are they innocent bystanders? Ross et al. (2013) show that inherited mtDNA point mutations lead to a premature aging phenotype in mice and “prime” the maternal lineage, interacting with subsequent somatic mutations to cause brain malformations and shorten lifespan
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