AbstractThe cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropeptides cholecystokinin (CCK), neuropeptide Y, gastrin-releasing peptide (GRP) and enkephalin. The CCK transcript of about 800 nt was present at very high levels and CCK-like peptides immunoreactive to a C-terminal CCK octapeptide antiserum were present in the cell line and its medium. This clonal neuronal cell line provides a unique model system to identify cis- and trans-acting factors responsible for neuron-specific expression and regulation of the CCK gene. Further-more, the pluripotent properties of the undifierentiated cell line may open studies on neuronal differentiation at the level of co-expression of neuropeptides and transmitters
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional prot...
Elucidating some molecular mechanisms and biochemistry of brain tumours is an important step towards...
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional prot...
AbstractThe cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropep...
AbstractRegulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cel...
AbstractExpression of the cholecystokinin (CCK), gastrin and enkephalin A genes were studied by Nort...
The gastrointestinal tract is a major site for production and release of peptide hormones. Several o...
Cholecystokinin (CCK) is a regulatory peptide that is primarily expressed in two adult cell types: e...
Gastrin and its carboxyl-terminal homolog cholecystokinin (CCK) exert a variety of biological action...
AbstractSince the nucleotide sequence of cholecystokinin (CCK) cDNA was found in the rat gene, we ap...
Research on digestive peptides in brain started in 1975 with the discovery of peptides of the gastri...
Cholecystokinin (CCK) is a polypeptide hormone which is produced in both the upper intestine and the...
Enteroendocrine cells such as duodenal cholecystokinin (CCK cells) are generally thought to be confi...
In this thesis the in vitro release of immunoreactive CCK₈ (iCCK₈) from rat central nervous system p...
The presence of cholecystokinin and gastrin has been reported in the hypothalamohypophyseal system. ...
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional prot...
Elucidating some molecular mechanisms and biochemistry of brain tumours is an important step towards...
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional prot...
AbstractThe cholinergic human neuroepithelioma cell line SK-N-MCIXC expressed mRNAs for the neuropep...
AbstractRegulation of cholecystokinin (CCK) expression was studied in the human neuroepithelioma cel...
AbstractExpression of the cholecystokinin (CCK), gastrin and enkephalin A genes were studied by Nort...
The gastrointestinal tract is a major site for production and release of peptide hormones. Several o...
Cholecystokinin (CCK) is a regulatory peptide that is primarily expressed in two adult cell types: e...
Gastrin and its carboxyl-terminal homolog cholecystokinin (CCK) exert a variety of biological action...
AbstractSince the nucleotide sequence of cholecystokinin (CCK) cDNA was found in the rat gene, we ap...
Research on digestive peptides in brain started in 1975 with the discovery of peptides of the gastri...
Cholecystokinin (CCK) is a polypeptide hormone which is produced in both the upper intestine and the...
Enteroendocrine cells such as duodenal cholecystokinin (CCK cells) are generally thought to be confi...
In this thesis the in vitro release of immunoreactive CCK₈ (iCCK₈) from rat central nervous system p...
The presence of cholecystokinin and gastrin has been reported in the hypothalamohypophyseal system. ...
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional prot...
Elucidating some molecular mechanisms and biochemistry of brain tumours is an important step towards...
Alternative splicing of genes generates novel mRNAs, leading to the evolution of new functional prot...