AbstractThe co-culture of mouse peritoneal macrophages and Lewis lung carcinoma cells induces the relase of a metal-dependent type IV collagen-degrading proteinase which is not produced in detactable amounts by either cell type cultivated alone. Conditioned media of the co-cultures degrade both pepsin-extracted type IV collagen from human placenta and mouse type IV procollagen. Thus macrophages can interact with tumor cells to degrade basement membrane type IV collagen: this might be of importance to allow cancer invasion and metastasis
Human macrophages have been implicated in connective tissue remodeling, however, little is known abo...
<p>A: Immunofluorescent staining for laminin (red), a component of the basement membrane was perform...
Type IV and interstitial collagenolytic activities were compared in human malignant and normal troph...
AbstractThe co-culture of mouse peritoneal macrophages and Lewis lung carcinoma cells induces the re...
Matrix metalloproteinase 2 (MMP-2) activation has been described as a "master switch" which triggers...
The underlying basement membrane is degraded during progression of breast and colon carcinoma. Thus,...
Proteolytic degradation of basement membrane influences the cell behavior during important processes...
AbstractA protease degrading type IV collagen was purified more than 8000-fold from human stomach ca...
Using both human and murine cell lines, we show that malignant cells are able to invade through base...
Degradation of interstitial collagens probably takes place through different enzymatic mechanisms th...
AbstractType IV collagenase is a metalloproteinase associated with metastatic tumor cells. It specif...
We have studied the role of the extracellular matrix and host cells in tumor progression and tumor i...
A type IV collagenolytic metalloproteinase secreted by human monocytes/macrophages has been isolated...
Tumor progression is controlled by signals from cellular and extra-cellular microenvironment includi...
AbstractA fibrosarcoma cell line transfected with the matrix metalloproteinase MT1 MMP showed an enh...
Human macrophages have been implicated in connective tissue remodeling, however, little is known abo...
<p>A: Immunofluorescent staining for laminin (red), a component of the basement membrane was perform...
Type IV and interstitial collagenolytic activities were compared in human malignant and normal troph...
AbstractThe co-culture of mouse peritoneal macrophages and Lewis lung carcinoma cells induces the re...
Matrix metalloproteinase 2 (MMP-2) activation has been described as a "master switch" which triggers...
The underlying basement membrane is degraded during progression of breast and colon carcinoma. Thus,...
Proteolytic degradation of basement membrane influences the cell behavior during important processes...
AbstractA protease degrading type IV collagen was purified more than 8000-fold from human stomach ca...
Using both human and murine cell lines, we show that malignant cells are able to invade through base...
Degradation of interstitial collagens probably takes place through different enzymatic mechanisms th...
AbstractType IV collagenase is a metalloproteinase associated with metastatic tumor cells. It specif...
We have studied the role of the extracellular matrix and host cells in tumor progression and tumor i...
A type IV collagenolytic metalloproteinase secreted by human monocytes/macrophages has been isolated...
Tumor progression is controlled by signals from cellular and extra-cellular microenvironment includi...
AbstractA fibrosarcoma cell line transfected with the matrix metalloproteinase MT1 MMP showed an enh...
Human macrophages have been implicated in connective tissue remodeling, however, little is known abo...
<p>A: Immunofluorescent staining for laminin (red), a component of the basement membrane was perform...
Type IV and interstitial collagenolytic activities were compared in human malignant and normal troph...