Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett's esophagus longer than 10 cm
- Herrero, Lorenza Alvarez
- van Vilsteren, Frederike G.I.
- Pouw, Roos E.
- ten Kate, Fiebo J.W.
- Visser, Mike
- Seldenrijk, Cornelis A.
- van Berge Henegouwen, Mark I.
- Fockens, Paul
- Weusten, Bas L.A.M.
- Bergman, Jaques J.G.H.M.
DOIAbstract
BackgroundRadiofrequency ablation (RFA) is safe and effective for eradicating Barrett's esophagus (BE) and BE-associated early neoplasia. Most RFA studies have limited the baseline length of BE (<10 cm), and therefore little is known about RFA for longer BE.ObjectiveTo assess the safety and efficacy of RFA with or without prior endoscopic resection (ER) for BE ≥10 cm containing neoplasia.DesignProspective trial.SettingTwo tertiary-care centers.PatientsThis study involved consecutive patients with BE ≥10 cm with early neoplasia.InterventionFocal ER for visible abnormalities, followed by a maximum of 2 circumferential and 3 focal RFA procedures every 2 to 3 months until complete remission.Main Outcome MeasurementsComplete remission, defined a...
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