AbstractThe study of the influence of intracellular pH (pHi) changes on the mechanism underlying pancreatic β-cell bursting has been hampered by concomitant effects on the activity of background ATP-dependent K+ (K-ATP) channels. β-cells were made to burst in the absence of active K-ATP channels by raising external Ca2+ in the presence of 11 mM glucose and tolbutamide. An alkalinizing pH; shift (exposure to 20 mM NH4C1) increased the burst active phase duration. Conversely, an acidifying shift (NH4Cl withdrawal) suppressed the electrical activity. This is the mirror image of the effects recorded in the absence of tolbutamide. Glibenclamide and quinine suppressed the alkalinization-evoked hyperpolarization. This study emphasizes the differen...
Based on the observation that potassium ions are compartmentalized near the surface of pancreatic be...
Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and in...
AbstractGlucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated...
AbstractThe study of the influence of intracellular pH (pHi) changes on the mechanism underlying pan...
AbstractMeasurements of the effects of NH3/NH4+ on glucose-induced electrical activity in β-cells fr...
AbstractThe pancreatic β-cell displays an electrical activity consisting of spike bursts and silent ...
AbstractThe effects of bicarbonate buffer (HCO−3/CO2) on the activity of the two K+ channels propose...
1. The effects of intracellular pH (pHi) on the ATP-sensitive K+ channel (K+ATP channel) from mouse ...
Based on the existence of ATP-sensitive potassium channels in the plasma membrane of pancreatic beta...
Since their discovery in pancreatic p-cells, ATP-sensitive K+ channels in the cell membrane have bee...
AbstractIn pancreatic β-cells, K,ATP channels respond to changes in glucose to regulate cell excitab...
Since their discovery in pancreatic ß-cells, ATP-sensitive K+ channels in the cell membrane have bee...
The electrical activity of pancreatic beta-cells, which has been closely correlated both with intrac...
AbstractWe have studied the effects of changes of intracellular ATP concentration ([ATP]i) on the ac...
Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depen...
Based on the observation that potassium ions are compartmentalized near the surface of pancreatic be...
Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and in...
AbstractGlucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated...
AbstractThe study of the influence of intracellular pH (pHi) changes on the mechanism underlying pan...
AbstractMeasurements of the effects of NH3/NH4+ on glucose-induced electrical activity in β-cells fr...
AbstractThe pancreatic β-cell displays an electrical activity consisting of spike bursts and silent ...
AbstractThe effects of bicarbonate buffer (HCO−3/CO2) on the activity of the two K+ channels propose...
1. The effects of intracellular pH (pHi) on the ATP-sensitive K+ channel (K+ATP channel) from mouse ...
Based on the existence of ATP-sensitive potassium channels in the plasma membrane of pancreatic beta...
Since their discovery in pancreatic p-cells, ATP-sensitive K+ channels in the cell membrane have bee...
AbstractIn pancreatic β-cells, K,ATP channels respond to changes in glucose to regulate cell excitab...
Since their discovery in pancreatic ß-cells, ATP-sensitive K+ channels in the cell membrane have bee...
The electrical activity of pancreatic beta-cells, which has been closely correlated both with intrac...
AbstractWe have studied the effects of changes of intracellular ATP concentration ([ATP]i) on the ac...
Summary: Insulin secretion from pancreatic β cells in response to high glucose (HG) critically depen...
Based on the observation that potassium ions are compartmentalized near the surface of pancreatic be...
Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and in...
AbstractGlucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated...