Tranexamic Acid for Spontaneous Intracerebral Hemorrhage: A Randomized Controlled Pilot Trial (ISRCTN50867461)

Sprigg, Nikola
Renton, Cheryl J.
Dineen, Robert A.
Kwong, Yune
Bath, Philip M.W.

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Publication date

July 2014

DOI

10.1016/j.jstrokecerebrovasdis.2013.11.007

Publisher

National Stroke Association. Published by Elsevier Inc.

ISSN

1052-3057

Citation count (estimate)

Abstract

BackgroundSpontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large CRASH-2 trial. The CRASH-2 ICH substudy found that TA nonsignificantly reduced mortality and dependency in traumatic ICH. The aim of this study was to assess the feasibility of performing a randomized controlled trial of tranexamic acid in spontaneous ICH, ahead of a definitive study.MethodsWe performed a single-center, prospective, randomized (2:1), double-blind, placebo-controlled blinded endpoint trial of TA (intravenous 1 g bolus, 1 g infusion/8 h) in acute (<24 hours) spontaneous ICH. The pri...