IκB kinases (IKKs) are key components of NF-κB signaling pathways in innate immunity and inflammation. Surprisingly, three recent reports implicate IKKs in Drosophila in seemingly unrelated functions, including non-apoptotic caspase activation and cytoskeleton organization
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensa...
AbstractPhosphorylation of IκBs—the cytoplasmic inhibitors of the NF-κB transcription factors—is the...
In Drosophila, the Immune Deficiency (IMD) pathway is indispensable for proper innate immune respons...
SummaryCaspase activation has been extensively studied in the context of apoptosis. However, caspase...
Two new papers (Kuranaga et al., 2006; Oshima et al., 2006) describe a previously uncharacterized Dr...
SummaryDifferentiated cells assume complex shapes through polarized cell migration and growth. These...
SummaryDistinct signaling pathways activate the NF-κB family of transcription factors. The canonical...
The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-κB signaling cassette ...
The IKK kinase complex is the core element of the NF-kB cascade. It is essentially made of two kinas...
Background: Activation of the transcription factor NF-κB by cytokines is rapid, mediated through the...
SummaryThe IκB kinase complex (IKK) is a key regulator of immune responses, inflammation, cell survi...
Selective autophagy is a catabolic process with which cellular material is specifically targeted for...
AbstractIκB kinase-α and -β (IKK-α and IKK-β), the catalytic subunits of the IKK complex, phosphoryl...
The ability to coordinate membrane trafficking events in space and time is of fundamental importance...
Stimulation of the Drosophila immune response activates NF-kappaB and JNK signaling pathways. For ex...
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensa...
AbstractPhosphorylation of IκBs—the cytoplasmic inhibitors of the NF-κB transcription factors—is the...
In Drosophila, the Immune Deficiency (IMD) pathway is indispensable for proper innate immune respons...
SummaryCaspase activation has been extensively studied in the context of apoptosis. However, caspase...
Two new papers (Kuranaga et al., 2006; Oshima et al., 2006) describe a previously uncharacterized Dr...
SummaryDifferentiated cells assume complex shapes through polarized cell migration and growth. These...
SummaryDistinct signaling pathways activate the NF-κB family of transcription factors. The canonical...
The Drosophila immune deficiency (IMD) signaling cascade regulates the IKK/NF-κB signaling cassette ...
The IKK kinase complex is the core element of the NF-kB cascade. It is essentially made of two kinas...
Background: Activation of the transcription factor NF-κB by cytokines is rapid, mediated through the...
SummaryThe IκB kinase complex (IKK) is a key regulator of immune responses, inflammation, cell survi...
Selective autophagy is a catabolic process with which cellular material is specifically targeted for...
AbstractIκB kinase-α and -β (IKK-α and IKK-β), the catalytic subunits of the IKK complex, phosphoryl...
The ability to coordinate membrane trafficking events in space and time is of fundamental importance...
Stimulation of the Drosophila immune response activates NF-kappaB and JNK signaling pathways. For ex...
Caspases provide vital links in non-apoptotic regulatory networks controlling inflammation, compensa...
AbstractPhosphorylation of IκBs—the cytoplasmic inhibitors of the NF-κB transcription factors—is the...
In Drosophila, the Immune Deficiency (IMD) pathway is indispensable for proper innate immune respons...
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