AbstractTelomerase activity is upregulated in most types of malignant tumor. Highly selective small molecule inhibitors will be needed to understand the biological basis for this observation and to determine if telomerase is a viable target for chemotherapy
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, ...
Stabilization of telomere length in chromosomes by an RNA-dependent DNA polymerase (telomerase) appe...
Telomerase is the specialized reverse transcriptase responsible for the de novo synthesis of telomer...
AbstractTelomerase activity is upregulated in most types of malignant tumor. Highly selective small ...
AbstractThe continuous growth of advanced malignancies almost universally correlates with the reacti...
AbstractTelomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chro...
The continuous growth of advanced malignancies almost universally correlates with the reactivation o...
Since telomere integrity is required to guarantee the unlimited replicative potential of cancer cell...
AbstractInhibition of telomerase is an exciting therapeutic target, since it is required for the lon...
The management of malignant disease remains one of the most challenging areas of modern medicine. Th...
AbstractSince telomere integrity is required to guarantee the unlimited replicative potential of can...
The objective of this literature review project is to investigate current therapeutics involved in t...
Maintenance of telomeres - specialized complexes that protect the ends of chromosomes is undertaken ...
Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, deve...
AbstractThe expression of telomerase in approximately 85% of cancers and its absence in the majority...
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, ...
Stabilization of telomere length in chromosomes by an RNA-dependent DNA polymerase (telomerase) appe...
Telomerase is the specialized reverse transcriptase responsible for the de novo synthesis of telomer...
AbstractTelomerase activity is upregulated in most types of malignant tumor. Highly selective small ...
AbstractThe continuous growth of advanced malignancies almost universally correlates with the reacti...
AbstractTelomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chro...
The continuous growth of advanced malignancies almost universally correlates with the reactivation o...
Since telomere integrity is required to guarantee the unlimited replicative potential of cancer cell...
AbstractInhibition of telomerase is an exciting therapeutic target, since it is required for the lon...
The management of malignant disease remains one of the most challenging areas of modern medicine. Th...
AbstractSince telomere integrity is required to guarantee the unlimited replicative potential of can...
The objective of this literature review project is to investigate current therapeutics involved in t...
Maintenance of telomeres - specialized complexes that protect the ends of chromosomes is undertaken ...
Many of the fundamental molecular mechanisms underlying tumor biology remain elusive and, thus, deve...
AbstractThe expression of telomerase in approximately 85% of cancers and its absence in the majority...
Telomeres are the specialized nucleoprotein structures associated with eukaryotic chromosomal ends, ...
Stabilization of telomere length in chromosomes by an RNA-dependent DNA polymerase (telomerase) appe...
Telomerase is the specialized reverse transcriptase responsible for the de novo synthesis of telomer...
DOI
Add to ORKG