AbstractG-protein-coupled receptors (GPCRs) are known to exist in dynamic equilibrium between inactive- and several active-state conformations, even in the absence of a ligand. Recent experimental studies on the β2 adrenergic receptor (β2AR) indicate that structurally different ligands with varying efficacies trigger distinct conformational changes and stabilize different receptor conformations. We have developed a computational method to study the ligand-induced rotational orientation changes in the transmembrane helices of GPCRs. This method involves a systematic spanning of the rotational orientation of the transmembrane helices (TMs) that are in the vicinity of the ligand for predicting the helical rotations that occur on ligand binding...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
With over 30% of available drugs targeting them, G protein-coupled receptors (GPCRs) are of signific...
SummaryG-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligan...
AbstractG-protein-coupled receptors (GPCRs) are known to exist in dynamic equilibrium between inacti...
SummaryG-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligan...
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that...
SummaryMechanism of G protein-coupled receptor (GPCR) activation and their modulation by functionall...
SummaryG protein-coupled receptors (GPCRs) are a class of versatile proteins that transduce signals ...
G protein-coupled receptors exist in a whole spectrum of conformations which are stabilised by the b...
SummaryG-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment to i...
<div><p>Recently available G-protein coupled receptor (GPCR) structures and biophysical studies sugg...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
With over 30% of available drugs targeting them, G protein-coupled receptors (GPCRs) are of signific...
SummaryG-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligan...
AbstractG-protein-coupled receptors (GPCRs) are known to exist in dynamic equilibrium between inacti...
SummaryG-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligan...
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that...
SummaryMechanism of G protein-coupled receptor (GPCR) activation and their modulation by functionall...
SummaryG protein-coupled receptors (GPCRs) are a class of versatile proteins that transduce signals ...
G protein-coupled receptors exist in a whole spectrum of conformations which are stabilised by the b...
SummaryG-protein-coupled receptors (GPCRs) transduce signals from the extracellular environment to i...
<div><p>Recently available G-protein coupled receptor (GPCR) structures and biophysical studies sugg...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G ...
With over 30% of available drugs targeting them, G protein-coupled receptors (GPCRs) are of signific...
SummaryG-protein-coupled receptors (GPCRs) can modulate diverse signaling pathways, often in a ligan...