SummaryGenetic programs, environmental factors, and electrical activity interact to drive the maturation of the brain. Although the cascade of transcription factors that leads to specification of the serotonergic phenotype has been well characterized, its interactions with electrical activity are not known. Here we show that spontaneous calcium spike activity in the hindbrain of developing Xenopus laevis larvae modulates the specification of serotonergic neurons via regulation of expression of the Lmx1b transcription factor. Activity acts downstream of Nkx2.2 but upstream of Lmx1b, leading to regulation of the serotonergic phenotype. Using global manipulation of activity and targeted alteration of Lmx1b expression, we also demonstrate that ...
Serotonin (5−HT) plays an important role in shaping the activity of the spinal networks underlying l...
Neural control of behaviour during development is a complicated orchestration of gene expression, ne...
Background: Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in e...
SummaryGenetic programs, environmental factors, and electrical activity interact to drive the matura...
In this article we review our research on the development and intrinsic neuromodulation of a spinal ...
We are intrigued by how electrical and intracellular calcium activity of neurons can regulate neurot...
Brainstem neurons modulate the rhythmic output of spinal locomotor circuitry in adult vertebrates, b...
We are intrigued by how electrical and intracellular calcium activity of neurons can regulate neurot...
The LIM homeodomain transcription factor Lmx1b is a key factor in the specification of the serotoner...
SummaryTo execute accurate movements, animals must continuously adapt their behavior to changes in t...
Specification of neurotransmitters is a crucial and fundamental aspect of development. It allows the...
Specification of neurotransmitters is a crucial and fundamental aspect of development. It allows the...
The neurotransmitter serotonin has been implicated in a range of complex neurological disorders link...
The neurotransmitter serotonin has been implicated in a range of complex neurological disorders link...
AbstractHow a common neurotransmitter phenotype specified in neurons of different origins is an outs...
Serotonin (5−HT) plays an important role in shaping the activity of the spinal networks underlying l...
Neural control of behaviour during development is a complicated orchestration of gene expression, ne...
Background: Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in e...
SummaryGenetic programs, environmental factors, and electrical activity interact to drive the matura...
In this article we review our research on the development and intrinsic neuromodulation of a spinal ...
We are intrigued by how electrical and intracellular calcium activity of neurons can regulate neurot...
Brainstem neurons modulate the rhythmic output of spinal locomotor circuitry in adult vertebrates, b...
We are intrigued by how electrical and intracellular calcium activity of neurons can regulate neurot...
The LIM homeodomain transcription factor Lmx1b is a key factor in the specification of the serotoner...
SummaryTo execute accurate movements, animals must continuously adapt their behavior to changes in t...
Specification of neurotransmitters is a crucial and fundamental aspect of development. It allows the...
Specification of neurotransmitters is a crucial and fundamental aspect of development. It allows the...
The neurotransmitter serotonin has been implicated in a range of complex neurological disorders link...
The neurotransmitter serotonin has been implicated in a range of complex neurological disorders link...
AbstractHow a common neurotransmitter phenotype specified in neurons of different origins is an outs...
Serotonin (5−HT) plays an important role in shaping the activity of the spinal networks underlying l...
Neural control of behaviour during development is a complicated orchestration of gene expression, ne...
Background: Alterations in neurotransmitter phenotypes of specific neurons can cause imbalances in e...