AbstractFlux of substrate and charge mediated by three cloned excitatory amino acid transporters widely expressed in human brain were studied in voltage-clamped Xenopus oocytes. Superfusion of l-glutamate or d-aspartate resulted in currents due in part to electrogenic Na+ cotransport, which contributed 1 net positive charge per transport cycle. A significant additional component of the currents was due to activation of a reversible anion flux that was not thermodynamically coupled to amino acid transport. The selectivity sequence of this ligand-activated conductance was NO3− > I− > Br− > Cl− > F−. The results suggest that these proteins mediate both transporter- and channel-like modes of permeation, providing a potential mechanism for dampe...
SummaryExcitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synapt...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
AbstractFlux of substrate and charge mediated by three cloned excitatory amino acid transporters wid...
Application of L-glutamate activates ionic currents in voltage-clamped Xenopus oocytes expressing cl...
AbstractCurrents mediated by a glutamate transporter cloned from human motor cortex were measured in...
The kinetic properties of the excitatory amino acid transporter EAAT2 were studied using rapid appli...
AbstractTo localize functionally significant domains in the amino acid transporters of mouse brain m...
Excitatory amino acid transporters (EAATs) are secondary active, electrogenic transporters which tra...
Excitatory amino acid transporters (EAATs) mediate two distinct transport processes, a stoichiometri...
Although a glutamate-gated chloride conductance with the properties of a sodium-dependent glutamate ...
AbstractThe excitatory amino acid transporter EAAC1 is an electrogenic Na+- and K+-gradient-driven t...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
SummaryExcitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synapt...
SummaryExcitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synapt...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
AbstractFlux of substrate and charge mediated by three cloned excitatory amino acid transporters wid...
Application of L-glutamate activates ionic currents in voltage-clamped Xenopus oocytes expressing cl...
AbstractCurrents mediated by a glutamate transporter cloned from human motor cortex were measured in...
The kinetic properties of the excitatory amino acid transporter EAAT2 were studied using rapid appli...
AbstractTo localize functionally significant domains in the amino acid transporters of mouse brain m...
Excitatory amino acid transporters (EAATs) are secondary active, electrogenic transporters which tra...
Excitatory amino acid transporters (EAATs) mediate two distinct transport processes, a stoichiometri...
Although a glutamate-gated chloride conductance with the properties of a sodium-dependent glutamate ...
AbstractThe excitatory amino acid transporter EAAC1 is an electrogenic Na+- and K+-gradient-driven t...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
SummaryExcitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synapt...
SummaryExcitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synapt...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic tran...