Vitamin D and its binding protein in children with cystic fibrosis: A single center study

AbstractAimTo measure the level of VDBP (vitamin D binding protein) and serum 25-hydroxy vitamin D (25OHD) in order to assess its role as a nutritional marker in cystic fibrosis (CF). The relationship between vitamin DBP and immunoglobulin G (IgG) levels was assessed as well.MethodsThis is a cross-sectional observational study recruiting 50 patients diagnosed as having CF from the Allergy and Pulmonology Unit, Children’s Hospital, Cairo University, from May 2012 until May 2013, twenty age- and sex-matched healthy children were included as a control group. Vitamin DBP and 25OHD were measured using Elisa technique and total IgG was measured using the nephelometer method.ResultsThe CF group had significantly lower serum concentrations of DBP (p<0.012) and 25OHD (p<0.001) while IgG levels were within normal values (p