AbstractGenetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspects of the biology of the disease, but have had limited success in translating these findings to the clinic. In this review, we discuss the benefits and limitations of existing genetic models and recent advances in technologies (including high throughput sequencing and genome editing) that promise more predictive models. We summarize widely used biomarkers and behavioral tests for mouse models of AD and highlight best practices that will maximize translatability of preclinical findings
BACKGROUND: Late-onset Alzheimer\u27s disease (LOAD) is the most common form of dementia worldwide. ...
In the current minireview, we focus on genetic mouse models of Alzheimer’s disease (AD). Because var...
The increasing prevalence of Alzheimer's disease (AD) poses a considerable socio-economic challenge....
AbstractGenetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspect...
Genetic mouse models for Alzheimer\u27s disease (AD) have been widely used to understand aspects of ...
Animal models of human diseases that accurately recapitulate clinical pathology are indispensable fo...
Abstract Alzheimer’s disease (AD) is behaviorally identified by progressive memory impairment and pa...
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases ...
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases ...
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals w...
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals w...
AbstractAnimal models have been used for decades in the Alzheimer's disease (AD) research field and ...
BACKGROUND: New genetic and genomic resources have identified multiple genetic risk factors for late...
Late-onset Alzheimer\u27s disease (AD; LOAD) is the most common human neurodegenerative disease, how...
BACKGROUND: New genetic and genomic resources have identified multiple genetic risk factors for late...
BACKGROUND: Late-onset Alzheimer\u27s disease (LOAD) is the most common form of dementia worldwide. ...
In the current minireview, we focus on genetic mouse models of Alzheimer’s disease (AD). Because var...
The increasing prevalence of Alzheimer's disease (AD) poses a considerable socio-economic challenge....
AbstractGenetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspect...
Genetic mouse models for Alzheimer\u27s disease (AD) have been widely used to understand aspects of ...
Animal models of human diseases that accurately recapitulate clinical pathology are indispensable fo...
Abstract Alzheimer’s disease (AD) is behaviorally identified by progressive memory impairment and pa...
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases ...
The ability to investigate therapeutic interventions in animal models of neurodegenerative diseases ...
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals w...
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals w...
AbstractAnimal models have been used for decades in the Alzheimer's disease (AD) research field and ...
BACKGROUND: New genetic and genomic resources have identified multiple genetic risk factors for late...
Late-onset Alzheimer\u27s disease (AD; LOAD) is the most common human neurodegenerative disease, how...
BACKGROUND: New genetic and genomic resources have identified multiple genetic risk factors for late...
BACKGROUND: Late-onset Alzheimer\u27s disease (LOAD) is the most common form of dementia worldwide. ...
In the current minireview, we focus on genetic mouse models of Alzheimer’s disease (AD). Because var...
The increasing prevalence of Alzheimer's disease (AD) poses a considerable socio-economic challenge....