Intercalation of Anti-inflammatory Drugs Sodium Indomethacin into Nanocomposites of Mg-Al. Structural Characterization

AbstractLayered double hydroxides (LDH) have many applications as matrices in pharmaceutical fields. γ-Indomethacin is a non-steroidal anti-inflammatory drug (NSAID) and the salt Sodium Indomethacin (INDONa) have been used as host drugs to be intercalated into LDH. As consequence of salt formation a polymorph of indomethacin was obtained. Intercalated compound was prepared via ion exchange and co-precipitation. As consequence of the intercalation, the interlayer distance of the host increased. The NSAID and LDH-INDONa were characterized by XRD, FT-IR and drug content was determinate by UV spectroscopy. The highest percentage of INDONa load was observed in the LDH-CI incorporated by direct method (48.40 wt%)