Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses
- Liu, Yi
- Curlin, Marcel E.
- Diem, Kurt
- Zhao, Hong
- Ghosh, Ananta K.
- Zhu, Haiying
- Woodward, Amanda S.
- Maenza, Janine
- Stevens, Claire E.
- Stekler, Joanne
- Collier, Ann C.
- Genowati, Indira
- Deng, Wenjie
- Zioni, Rafael
- Corey, Lawrence
- Zhu, Tuofu
- Mullins, James I.
Publication date
May 2008
DOI Publisher
Elsevier BV ISSN
0042-6822 Citation count (estimate)
59Abstract
AbstractWhether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites
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