SummaryBromodomain functions as the acetyl-lysine binding domains to regulate gene transcription in chromatin. Bromodomains are rapidly emerging as new epigenetic drug targets for human diseases. However, owing to their transient nature and modest affinity, histone-binding selectivity of bromodomains has remained mostly elusive. Here, we report high-resolution crystal structures of the bromodomain-PHD tandem module of human transcriptional coactivator CBP bound to lysine-acetylated histone H4 peptides. The structures reveal that the PHD finger serves a structural role in the tandem module and that the bromodomain prefers lysine-acetylated motifs comprising a hydrophobic or aromatic residue at −2 and a lysine or arginine at −3 or −4 position...
The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of t...
LetterInternational audienceA key step in many chromatin-related processes is the recognition of his...
Elegant mechanisms of gene regulation have evolved to support specialised function and complexity in...
SummaryBromodomain functions as the acetyl-lysine binding domains to regulate gene transcription in ...
SummaryHistone lysine acetylation is central to epigenetic control of gene transcription. Bromodomai...
SummaryBromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine ac...
AbstractBromodomains, an extensive family of evolutionarily conserved protein modules originally fou...
Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emergi...
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylati...
Open access article. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Lice...
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylati...
AbstractBromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a uniqu...
Bromodomains, epigenetic readers that recognize acetylated lysine residues in histone tails, are pot...
SummaryBromodomains are epigenetic readers that are recruited to acetyllysine residues in histone ta...
Little is known about how combinations of histone marks are interpreted at the level of nucleosomes....
The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of t...
LetterInternational audienceA key step in many chromatin-related processes is the recognition of his...
Elegant mechanisms of gene regulation have evolved to support specialised function and complexity in...
SummaryBromodomain functions as the acetyl-lysine binding domains to regulate gene transcription in ...
SummaryHistone lysine acetylation is central to epigenetic control of gene transcription. Bromodomai...
SummaryBromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine ac...
AbstractBromodomains, an extensive family of evolutionarily conserved protein modules originally fou...
Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emergi...
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylati...
Open access article. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Lice...
Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylati...
AbstractBromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a uniqu...
Bromodomains, epigenetic readers that recognize acetylated lysine residues in histone tails, are pot...
SummaryBromodomains are epigenetic readers that are recruited to acetyllysine residues in histone ta...
Little is known about how combinations of histone marks are interpreted at the level of nucleosomes....
The bromodomain and extra-terminal (BET) protein BRD4 regulates gene expression via recruitment of t...
LetterInternational audienceA key step in many chromatin-related processes is the recognition of his...
Elegant mechanisms of gene regulation have evolved to support specialised function and complexity in...