Early-Stage Young Breast Cancer Patients: Impact of Local Treatment on Survival
- Bantema-Joppe, Enja J.
- de Munck, Linda
- Visser, Otto
- Willemse, Pax H.B.
- Langendijk, Johannes A.
- Siesling, Sabine
- Maduro, John H.
DOIAbstract
PurposeIn young women, breast-conserving therapy (BCT), i.e., lumpectomy followed by radiotherapy, has been associated with an increased risk of local recurrence. Still, there is insufficient evidence that BCT impairs survival. The aim of our study was to compare the effect of BCT with mastectomy on overall survival (OS) in young women with early-stage breast cancer.Methods and MaterialsFrom two Dutch regional population-based cancer registries (covering 6.2 million inhabitants) 1,453 women <40 years with pathologically T1N0–1M0 breast cancer were selected. Cox regression survival analysis was used to study the effect of local treatment (BCT vs. mastectomy) stratified for nodal stage on survival and corrected for tumor size, age, period of ...
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