Radiation-induced early temporal changes of IVIM-based diffusion and perfusion patterns of bone marrow predict the likelihood of hematological toxicity

Electronic Poster Session: MSK - Bone & Soft Tissue: no. 4465Intravoxel incoherent motion (IVIM) diffusion-weighted MRI offers the unique opportunity to simultaneously study the diffusion and perfusion changes in the bone marrow following whole-pelvis radiotherapy. We prospectively studied twenty-eight patients with cervical cancer who had paired IVIM MRI examinations before and at week-4 of treatment. We observed a distinctive positive trend of D (true diffusion coefficient) in patients who suffered hematological toxicity (HT), whilst D remained relatively stable in patients who did not suffer HT. In addition, f (perfusion fraction) increased following treatment, but this pattern was not unique to patients who suffered HT