Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 million cases of malaria every year, with a further 1.4 billion people at risk of infection [1-3]. Little is known about the genetic makeup of P. falciparum populations, despite variation in genetic diversity being a key factor in morbidity, mortality, and the success of malaria control initiatives. Here we analyze a worldwide sample of 519 P. falciparum isolates sequenced for two housekeeping genes (63 single nucleotide polymorphisms from around 5000 nucleotides per isolate). We observe a strong negative correlation between within-population genetic diversity and geographic distance from sub-Saharan Africa (R2 = 0.95) over Africa, Asia, and ...
ABSTARCT: Strong founder effects resulting from human migration out of Africa have led to geographic...
INTRODUCTION: The human malaria parasite, Plasmodium vivax, is proving more difficul...
Human travel to malaria endemic lowlands from epidemic highlands has been shown to increase the risk...
SummaryPlasmodium falciparum is distributed throughout the tropics and is responsible for an estimat...
Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 ...
Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 ...
BACKGROUND: Malaria parasite population genetic structure varies among areas of differing endemicity...
Understanding genomic variation and population structure of Plasmodium falciparum across Africa is n...
The genetic diversity of Plasmodium falciparum allows the molecular discrimination of otherwise micr...
Background. The population genetic structure of Plasmodium falciparum differs between endemic region...
Multilocus genotyping of microbial pathogens has revealed a range of population structures, with som...
The geographical distribution of single nucleotide polymorphism (SNP) in the mitochondrial genome of...
Multilocus genotyping of microbial pathogens has revealed a range of population structures, with som...
BACKGROUND: Selection by host immunity and antimalarial drugs has driven extensive adaptive evolutio...
Malaria is a major public health problem that is actively being addressed in a global eradication ca...
ABSTARCT: Strong founder effects resulting from human migration out of Africa have led to geographic...
INTRODUCTION: The human malaria parasite, Plasmodium vivax, is proving more difficul...
Human travel to malaria endemic lowlands from epidemic highlands has been shown to increase the risk...
SummaryPlasmodium falciparum is distributed throughout the tropics and is responsible for an estimat...
Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 ...
Plasmodium falciparum is distributed throughout the tropics and is responsible for an estimated 230 ...
BACKGROUND: Malaria parasite population genetic structure varies among areas of differing endemicity...
Understanding genomic variation and population structure of Plasmodium falciparum across Africa is n...
The genetic diversity of Plasmodium falciparum allows the molecular discrimination of otherwise micr...
Background. The population genetic structure of Plasmodium falciparum differs between endemic region...
Multilocus genotyping of microbial pathogens has revealed a range of population structures, with som...
The geographical distribution of single nucleotide polymorphism (SNP) in the mitochondrial genome of...
Multilocus genotyping of microbial pathogens has revealed a range of population structures, with som...
BACKGROUND: Selection by host immunity and antimalarial drugs has driven extensive adaptive evolutio...
Malaria is a major public health problem that is actively being addressed in a global eradication ca...
ABSTARCT: Strong founder effects resulting from human migration out of Africa have led to geographic...
INTRODUCTION: The human malaria parasite, Plasmodium vivax, is proving more difficul...
Human travel to malaria endemic lowlands from epidemic highlands has been shown to increase the risk...