Kynurenine monooxygenase (KMO) is an enzyme of the kynurenine (Kyn) pathway (KP), which is the major catabolic route of tryptophan. Kyn represents a branch point of the KP, being converted into the neurotoxin 3-hydroxykynurenine via KMO, neuroprotectant kynurenic acid, and anthranilic acid. As a result of this branch point, KMO is an attractive drug target for several neurodegenerative and/or neuroinflammatory diseases, especially Huntington's (HD), Alzheimer's (AD), and Parkinson's (PD) diseases. Although a neurological target, administration of KMO inhibitors in the periphery has demonstrated promising pharmacological results. In light of a recent crystal structure release and reports of preclinical candidates, here we provide a concise y...
SummaryMetabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to pl...
The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and generates a number o...
Introduction: The proven pathological alterations in the kynurenine pathway of tryptophan metabolism...
Kynurenine-3-monooxygenase (KMO) is an enzyme that relies on nicotinamide adenine dinucleotide phosp...
International audienceInhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tr...
Kynurenine-3-monooxygenase (KMO) is a mitochondrial enzyme in the kynurenine pathway (KP) through wh...
Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptophan degra...
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metab...
Dysregulation of the kynurenine pathway (KP) leads to imbalances in neuroactive metabolites associat...
Kynurenine-3-monooxygenase (KMO) is an important therapeutic target for several brain disorders that...
The kynurenine pathway produces NAD+ from L-tryptophan. Metabolites known as the kynurenines are pr...
Kynurenine 3-monooxygenase (KMO) is a flavoprotein which has been implicated in Huntington’s diseas...
a b s t r a c t Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of t...
AbstractKynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptopha...
We report on the development of a series of pyrimidine carboxylic acids that are potent and selectiv...
SummaryMetabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to pl...
The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and generates a number o...
Introduction: The proven pathological alterations in the kynurenine pathway of tryptophan metabolism...
Kynurenine-3-monooxygenase (KMO) is an enzyme that relies on nicotinamide adenine dinucleotide phosp...
International audienceInhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tr...
Kynurenine-3-monooxygenase (KMO) is a mitochondrial enzyme in the kynurenine pathway (KP) through wh...
Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptophan degra...
The kynurenine pathway is the major route for tryptophan metabolism in mammals. Several of the metab...
Dysregulation of the kynurenine pathway (KP) leads to imbalances in neuroactive metabolites associat...
Kynurenine-3-monooxygenase (KMO) is an important therapeutic target for several brain disorders that...
The kynurenine pathway produces NAD+ from L-tryptophan. Metabolites known as the kynurenines are pr...
Kynurenine 3-monooxygenase (KMO) is a flavoprotein which has been implicated in Huntington’s diseas...
a b s t r a c t Kynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of t...
AbstractKynurenine 3-monooxygenase (KMO) is an enzyme central to the kynurenine pathway of tryptopha...
We report on the development of a series of pyrimidine carboxylic acids that are potent and selectiv...
SummaryMetabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to pl...
The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and generates a number o...
Introduction: The proven pathological alterations in the kynurenine pathway of tryptophan metabolism...