Three different analysis platforms using LC-MS were successfully developed for pharmacokinetic (PK) studies of an antibody drug in serum. These analysis platforms can be selectively used for different types of protein drugs, which ranged from a very specific for a particular drug (antibody enrichment) to a less specific for any antibody drugs with an Fc domain (protein A enrichment), and to a very generic method that can be used for any protein drugs (albumin depletion method). In this manner, the three platforms will be applicable to a wide range of antibody therapeutic studies for different species. The analysis using an albumin depletion method (with sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)) achieved the detec...
LC-MS is a powerful method for the sensitive detection of proteins and peptides in biological fluids...
This paper represents the consensus views of a cross-section of companies and organizations from the...
Liquid chromatography coupled to tandem mass spectrometry (LC-MS) has been used in the last two deca...
Biotechnology increasingly delivers highly promising protein-based biopharmaceutical candidates to t...
Monoclonal antibodies (mAbs) are indispensable in the therapeutic arsenal, particularly in oncology ...
Driven by an increase in the geriatric population and the prevalence of chronic diseases such as can...
Protein Medications: Understanding them betterProtein medications that have been given to patients c...
Abstract Antibody-based therapeutics constitute a major growth area in medicine today. However, anti...
Over the past 10 years, there has been a remarkable increase in the use of LC-MS for the quantitativ...
The central theme of this thesis is the development of highly sensitive liquid chromatography - mass...
This thesis describes bioanalytical methods for generating fingerprints of biological systems for ex...
Protein Medications: Understanding them better Protein medications that have been given to patients ...
Depuis quelques années, la spectrométrie de masse est considérée comme la méthode de référence en ch...
Physiochemical degradation of therapeutic proteins in vivo during plasma circulation after administr...
Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pha...
LC-MS is a powerful method for the sensitive detection of proteins and peptides in biological fluids...
This paper represents the consensus views of a cross-section of companies and organizations from the...
Liquid chromatography coupled to tandem mass spectrometry (LC-MS) has been used in the last two deca...
Biotechnology increasingly delivers highly promising protein-based biopharmaceutical candidates to t...
Monoclonal antibodies (mAbs) are indispensable in the therapeutic arsenal, particularly in oncology ...
Driven by an increase in the geriatric population and the prevalence of chronic diseases such as can...
Protein Medications: Understanding them betterProtein medications that have been given to patients c...
Abstract Antibody-based therapeutics constitute a major growth area in medicine today. However, anti...
Over the past 10 years, there has been a remarkable increase in the use of LC-MS for the quantitativ...
The central theme of this thesis is the development of highly sensitive liquid chromatography - mass...
This thesis describes bioanalytical methods for generating fingerprints of biological systems for ex...
Protein Medications: Understanding them better Protein medications that have been given to patients ...
Depuis quelques années, la spectrométrie de masse est considérée comme la méthode de référence en ch...
Physiochemical degradation of therapeutic proteins in vivo during plasma circulation after administr...
Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pha...
LC-MS is a powerful method for the sensitive detection of proteins and peptides in biological fluids...
This paper represents the consensus views of a cross-section of companies and organizations from the...
Liquid chromatography coupled to tandem mass spectrometry (LC-MS) has been used in the last two deca...