Recurrent invasive pneumococcal disease in children: Underlying clinical conditions, and immunological and microbiological characteristics
- Alsina, Laia
- Basteiro, Maria G.
- Paz, Hector D. de
- Iñigo, Melania
- Sevilla, Mariona F. de
- Triviño, Miriam
- Juan, Manel
- Muñoz-Almagro, Carmen
DOIAbstract
[Purpose] Clinical, immunological and microbiological characteristics of recurrent invasive pneumococcal disease (IPD) in children were evaluated, differentiating relapse from reinfection, in order to identify specific risk factors for both conditions.[Methods] All patients <18 years-old with recurrent IPD admitted to a tertiary-care pediatric center from January 2004 to December 2011 were evaluated. An episode of IPD was defined as the presence of clinical findings of infection together with isolation and/or pneumococcal DNA detection by Real-Time PCR in any sterile body fluid. Recurrent IPD was defined as 2 or more episodes in the same individual at least 1 month apart. Among recurrent IPD, we differentiated relapse (same pneumococcal i...
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